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Description
FITC Armenian hamster Anti-Mouse/Human KLRG1 Antibody (S-R655)Product Specification Host Armenian hamster Antigen KLRG1 Synonyms Killer cell lectin like receptor subfamily G member 1; C type lectin domain family 15 member A; ITIM containing receptor MAFA L; MAFA like receptor; Mast cell function associated antigen; CLEC15A; MAFA; MAFAL Location Cell membrane Accession Q96E93 O88713 Clone Number S R655 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu, Ms Positive Sample C57BL 6 mouse
Product Specification
| Host | Armenian hamster |
| Antigen | KLRG1 |
| Synonyms | Killer cell lectin-like receptor subfamily G member 1; C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen; CLEC15A; MAFA; MAFAL |
| Location | Cell membrane |
| Accession | Q96E93、 O88713 |
| Clone Number | S-R655 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu, Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu, Ms |
Background
Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor primarily expressed on natural killer (NK) cells and antigen-experienced T cells, including CD8+ T cells, CD4+ T cells, and regulatory T cells (Tregs). It functions as a type II transmembrane glycoprotein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). KLRG1 binds to cadherins (such as E-cadherin, N-cadherin, and R-cadherin) on antigen-presenting cells (APCs) or tumor cells, inhibiting immune cell activation, proliferation, and cytotoxicity through the PI3K/AKT and AMPK pathways. In disease contexts, KLRG1 is implicated in various immune responses. In autoimmune diseases like primary biliary cholangitis and systemic lupus erythematosus, its expression correlates with disease severity. In cancer, KLRG1+ T cells are associated with immune evasion, and high KLRG1 expression in tumors is linked to poor prognosis. KLRG1 is also involved in viral infections, where it can inhibit T cell function and promote immune exhaustion. Ongoing research explores KLRG1 as a potential therapeutic target for modulating immune responses in cancer and autoimmune diseases.
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Exchange/Return Notes
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